Table I.

Effect of anti-CD40L Ab treatment on EAMG

TreatmentClinical Score (No./total)aMean Clinical ScoreaΔ Weight 5–9 wk (g)T Cell Proliferation (cpm)bAnti-Rat AChR Ab Titer (nM)c
01234
Anti-BSA0 /83 /83 /81 /82 /82.5−8 ± 201834 ± 25070
Anti-CD40L2 /82 /83 /81 /80 /81.46 ± 141904 ± 19022
  • a Evaluated 9 wk after the induction of EAMG and 5 wk after initiation of treatment. Representative experiment performed as in Fig. 1A, of three independent experiments.

  • b In response to Torpedo AChR (0.25 μg/ml), evaluated for three to four individual rats in each assay.

  • c Evaluated in pooled sera of rats, 5 wk after initiation of treatment. The anti-rat AChR titer of pooled sera before treatment was 40 nM.