Table I.

Relative binding affinity of DR0401- and DR0404-restricted VP16 epitopesa

IC50 0401 (μM)IC50 0404 (μM)
DR0401-restricted VP16 epitopes:
VP1658–69 ALFNRLLDDLGF24
VP16472–484 DFEFEQMFTDAMG0.50.5
DR0404-restricted VP16 epitopes:
VP16443–455 FDLEMLGDVESPS>50.005
  • a Underlined residue is the proposed first anchor for binding to the respective allele as determined by peptide truncation studies (data not shown).