Table I.

Thymic morphology and localization of SIV in neonatal macaques

Animal No.Days PostinfectionIn Situ HybridizationaImmunohistochemistryaHistopathb
68-9730
69-9730
102-9771
103-977++2
136-97141
137-9714+++3
190-9721++++0*
191-9721++0*
296-9750++0*
297-9750++0*
  • a Results of in situ hybridization and immunohistochemistry were quantified as follows: no positive cells, negative; one to five positive cells per section, 1+; five to 15 positive cells per 10× field, 2+; 15 to 30 positive cells per 10× field, 3+; >30 positive cells per 10× field, 4+.

  • b Histopathological grading of thymus morphology. The degree of thymic dysinvolution was subjectively quantified on a scale of 0–3 as follows: 0, within normal limits; 1, mild; 2, moderate; 3, severe. In addition, some animals had increased cortical thickness and increased cortical to medullary ratio compared to control animals and are indicated with an asterisk.