Table II.

Pattern of somatic mutations in VH186.2 sequences from WT and Cr2−/− mice

MouseMutation FrequencyR/Sa
CDR (expected = 4.9)bFramework region (expected = 2.6)b
WT6.110.82.8
Cr2 −/− 6.26.72.0
  • a Ratio of replacement (R) to silent (S) mutations.

  • b Expected R/S ratio, as described previously.