NO production by lung Mφ from wt, TNFR1−/−, and TNFR2−/− micea
| Mouse | Stimulusb | Mean μM NO2 (±SEM)c |
|---|---|---|
| wt | – | 40.5 ± 4.9 |
| + | 72.3 ± 5.0 | |
| TNFR1−/− | – | 25.9 ± 4.7 |
| + | 63.2 ± 6.3 | |
| TNFR2−/− | – | 34.9 ± 5.7 |
| + | 86.9 ± 4.1 |
a NO was measured as described in Materials and Methods. The data are expressed as mean μM NO2 ± SEM. Results are from eight mice per group.
b The stimulus was E. coli O111:B4 LPS (1 μg) plus IFN-γ (100 ng/ml).
c The mean value for TNFR2−/− mice exceeded (p < 0.01) that found for controls and TNFR1−/− mice. There was no statistical difference (p > 0.05) between controls and TNFR1−/− mice.