Table II.

NO production by lung Mφ from wt, TNFR1−/−, and TNFR2−/− micea

MouseStimulusbMean μM NO2 (±SEM)c
wt40.5 ± 4.9
+72.3 ± 5.0
TNFR1−/−25.9 ± 4.7
+63.2 ± 6.3
TNFR2−/−34.9 ± 5.7
+86.9 ± 4.1
  • a NO was measured as described in Materials and Methods. The data are expressed as mean μM NO2 ± SEM. Results are from eight mice per group.

  • b The stimulus was E. coli O111:B4 LPS (1 μg) plus IFN-γ (100 ng/ml).

  • c The mean value for TNFR2−/− mice exceeded (p < 0.01) that found for controls and TNFR1−/− mice. There was no statistical difference (p > 0.05) between controls and TNFR1−/− mice.