Table I.

Reduction of interstitial pulmonary eosinophilia following CXCR4 blockagea

OVA + Control AbOVA + α-CXCR4 Ab
MouseEosinophilia (%)ScoreMouseEosinophilia (%)Score
170+5 710+2
270+4 825+2
380+4 925+2
475+51030+2
570+51135+2
670+51235+2
1390+51935+2
1470+42020+2
1580+52160+3
1680+52215+2
1770+42320+1
1850+32415+1
2590+53110+2
2670+53280+4
2795+53335+2
2860+43465+3
2985+53530+3
3080+43620+2
X =75.5 ± 10.34.5 ± 2.631.4 ± 18.62.1 ± 0.6
  • a An estimation of the percentage of eosinophils within the infiltrate in OVA + rabbit Ig-treated controls and OVA + anti-CXCR4 Ab-treated mice was made by counting 200 cells in one randomly selected peribronchiolar infiltrate and determining the number of eosinophils present. A semi-quantitative scoring system was used to estimate the size of lung infiltrates, where +5 signifies a large widespread infiltrate around the majority of vessels and bronchioles, and +1 signifies a small number of inflammatory foci. Data presented for three experiments. Averages and SDs for each column are also indicated.