Table III.

THC inhibits antitumor immune protection in BALB/c micea

Tumor Rechallenge Dose (no. of L1C2 cells)# of Mice Rejecting Tumor/Total
THCDiluent
1× 1058 /88 /8
2× 1055 /88 /8
3× 1054 /8b8 /8
  • a Following pretreatment with THC or diluent control for 2 wk, BALB/c mice were immunized with 5 × 105 irradiated L1C2 cells by weekly s.c. injection for 6 wk. The mice were rechallenged with 1–3 × 105 L1C2 cells. Mice were observed for tumor growth for 40 days following rechallenge.

  • b The two treatment groups (THC, diluent) were compared with respect to the proportion rejecting the tumor using Fisher’s Exact Test for 2 × 2 tables; p = 0.038 at dose = 3 × 105.