Table I.

Effect of THC on tumor and splenocyte cytokine productiona

At the Tumor SiteSplenocytes from 3LL Tumor-Bearing Mice
TGF-β (ng/ml/500 mg tumor)IL-10 (pg/ml/500 mg tumor)IFN-γ (pg/ml/500 mg tumor)TGF-β (ng/ml/106 cells)IL-10 (pg/ml/106 cells)IFN-γ (pg/ml/106 cells)
Diluent control18.7 ± 1.5819.0 ± 192190.0 ± 20.91.2 ± 0.118.3 ± 1.037.3 ± 6.5
THC (5 mg/kg)35.4 ± 3.21491.3 ± 166.173.2 ± 2.31.8 ± 0.139.6 ± 9.521.1 ± 0.5
p Value<0.01<0.05<0.05<0.01<0.05<0.05
  • a Nonnecrotic tumors and spleens were isolated from the 3LL tumor-bearing mice. Mice were treated with THC or diluent control using the dosing and injection schedule as described above. TGF-β, IL-10, and IFN-γ levels were evaluated in tumor homogenates and splenocyte culture supernatants by cytokine-specific ELISA.