Table II.

Contrary results supporting two opposing notions about the effector cells of CHS

CD4+ T Cells Mediate CHSCD8+ T Cells Mediate CHS
Nickel-specific T cells in nickel-allergic patientsCD4+ T cells (7-10)CD8+ T cells (20)
In vivo depletion of CD4+ T cellsDecreased CHS (12)Enhanced CHS (21)
In vivo depletion of CD8+ T cellsNormal CHS (12)Inhibited CHS (21)
In vitro depletion of CD4+ T cellsDecreased transfer (14, 15)Enhanced transfer (21)
In vitro depletion of CD8+ T cellsNormal transfer (14, 15)Decreased transfer (21)
MHC class I-deficient miceNormal CHS (14)Abolished CHS (22)
Polarization in hapten-primed LNCsIFN-γ-producting CD4+ Th1 cells (11, 18)IFN-γ-producing CD8+ Tc1 T cells (26)