Table III.

Local cytokine levels of wild-type and IFN-γ-deficient micea

Cytokine (pg/ml)Wild-Type MiceDay 1IFN-γ-Deficient MiceDay 1
90 min4 h90 min4 h
IL-18480 ± 100580 ± 90700 ± 120510 ± 90650 ± 70810 ± 100
TNFα570 ± 90300 ± 90100 ± 40500 ± 60250 ± 50110 ± 50
IL-1β430 ± 1001830 ± 280630 ± 130300 ± 701600 ± 350680 ± 120
  • a Synovial tissue levels of IL-18, TNFα, and IL-1β during onset of SCW arthritis in wild-type and IFN-γ-deficient mice. For each time point, six mice per group were used. For details, see Table I. This experiment was repeated once with roughly the same outcome. *, p < 0.05, Mann-Whitney U test compared to naive mice.