Table II.

Local cytokine levels after anti-IL-18 treatmenta

Cytokine (pg/ml)Time PointControl IgsAnti-IL-18
IL-1890 min591 ± 130240 ± 90*
4 h700 ± 120300 ± 60*
Day 1NDND
TNFα90 min580 ± 90170 ± 40*
4 h340 ± 90130 ± 80*
Day 1NDND
IL-1β90 min350 ± 100140 ± 50*
4 h1730 ± 180240 ± 80*
Day 1630 ± 130380 ± 60*
  • a Synovial tissue levels of IL-18, TNFα, and IL-1β after anti-IL-18 treatment. Anti-IL-18 Abs were injected 2 h before induction of SCW arthritis. For each time point, six mice per group were used. For details, see Table I. This experiment was repeated once with roughly the same outcome. *, p < 0.05, Mann-Whitney U test compared to naive mice.