Table I.

Treatment of M. tuberculosis-infected mice with mAb to α4 or α4β7 integrin leads to a detrimental lung response

mAb TreatmentaLymphocytebGranulocytebBacterial loadcn
Untreated9.92 ± 1.143.88 ± 0.716.74 ± 0.155
Control mAb10.4 ± 0.284.88 ± 0.836.60 ± 0.185
DATK32 (anti-α4β7 integrin)6.48 ± 0.94d11.0 ± 2.60∗7.02 ± 0.155
PS/2 (anti-α4 integrin)6.10 ± 0.57∗10.5 ± 2.07∗7.22 ± 0.254
  • a The mice were infected for 14 days with aerosol M. tuberculosis and then injected (i.p.) with rat mAb on day 14, then on alternate days until day 28 postaerosol infection.

  • b Lung tissues were collected 28 days after aerosol infection of M. tuberculosis. Lymphocyte and granulocyte populations were defined by FACS analysis. Results are expressed as mean cell number × 106 ± SEM/lung.

  • c Lung tissues were collected at 28 days after aerosol infection with M. tuberculosis. Results are expressed as mean log10 CFU ± SEM/lung.

  • d The significance of the differences in cell number and CFU between untreated and mAb-treated mice was compared using the Mann-Whitney test (∗, p < 0.05).