Table I.

Summary of T cell reactivity to OVA323–339 truncationsa

PeptideT Cell Clone
DO11.10OT-IIA6A7A1
323–3390.0040.20.060.0330.0027
324–3390.0110.12 >100 0.090.003
325–3390.0040.2>100 5.2 0.018
326–3390.0040.21>100>100 0.12
327–3390.040.33>100>1006
328–339 0.4 4.8>100>10050
329–33925 30 >100>100>100
323–3370.025 30 0.060.040.003
323–336 1 >1000.1150.10.003
323–3350.35>1000.150.06 0.15
323–33445>1000.20.162.5
  • a The concentration (μM) of peptide required to reach the half-maximal proliferation induced by OVA323–339 is shown. The values in bold indicate the edges of the T cell epitopes as determined by the requirement for a 100-fold increase in peptide to reach the half-max.