Table I.

Cytokine profiles by MLN cells following in vitro Ag stimulation during infection with T. spiralisa

iNOS−/+iNOS−/−
Day 0Day 13 p.i.Day 0Day 13 p.i.
IL-2 (U/ml)0 ± 06.5 ± 3.1b0 ± 025.6 ± 5.6b c
IFN-γ (U/ml)0 ± 03.5 ± 0.2b32.5 ± 2.0c38.1 ± 2.8c
IL-4 (U/ml)0.5 ± 0.312.5 ± 3.1b0 ± 04.1 ± 2.1b c
IL-5 (U/ml)0.9 ± 0.74.4 ± 1.3b0 ± 00 ± 0c
TNF-α (U/ml)0 ± 011.0 ± 2.9b0 ± 01.0 ± 1.0c
  • a Data are shown as mean ± SEM; iNOS−/+ (n = 6), iNOS−/− (n = 7). This table is representative of two experiments.

  • b , Significant difference between infected and uninfected animals (p < 0.05).

  • c , Significant difference between iNOS−/+ and iNOS−/− (p < 0.05).