Table I.

Peripheral lymphoid organ cell countsa

Cell Counts, ×10−7CD4 T CellsCD8 T CellsB Cells
Tg negativeIns-TCA4Tg negativeIns-TCA4Tg negativeIns-TCA4
Spleen2.3 ± 0.451.9 ± 0.211.2 ± 0.311.1 ± 0.010.0 ± 2.410.4 ± 0.62
Lymph node2.1 ± 0.501.7 ± 0.121.1 ± 0.251.2 ± 0.062.1 ± 0.102.2 ± 0.31
Total4.5 ± 0.953.5 ± 0.322.3 ± 0.562.3 ± 0.0612.1 ± 2.312.6 ± 0.80
  • a Lymph nodes (cervical, axillary, inguinal, and mesenteric) and spleen were stained for CD4, CD8, and B220; total cell counts were multiplied by percentage of cells staining positive for each lymphocyte marker (three mice per group, age-matched littermates).

  • b Tg, transgene.