Table IV.

Effect of glomerular Mφ isolated from rats with NTN at days 2, 4, and 7 upon MC apoptosis, mitosis, and cell numbera

Day 2 MφDay 2 Mφ + l-NMMADay 4 MφDay 7 Mφ
Apoptosis at 16 h (% of control)493 ± 23136 ± 5b261 ± 11487 ± 16
Mitosis at 16 h (% of control)19 ± 1283 ± 18b38 ± 6023 ± 29
MC number at 24 h (% of control)73 ± 999 ± 10b85 ± 681 ± 9
  • a Control MC apoptosis 0.68 ± 0.04%, mitosis 3.8 ± 0.7%, and MC number 1729 ± 68%. The addition of l-NMMA (100 μM) to cocultures with day 2 Mφ shows partial abrogation of the Mφ-induced effects on MC. d-NMMA in coculture with day 2 Mφ were comparable to no additive and the data have been omitted for clarity.

  • b , p < 0.05 compared to day 2 Mφ (n = 3).