Table III.

COX-2 inhibition in vivo augments anti-CD40-stimulated IL-12 production by APCa

MiceIL-12 Production (pg/ml/72 h/5 × 106 cells)
Control non-tumor bearer209.3 ± 7.6*
Untreated 3LL bearer104.2 ± 12.2
CV-3LL106.6 ± 9.8
4SC7-3LL94.0 ± 10.0
1ASE7-3LL178.8 ± 9.5*
SC-58236-treated 3LL bearer233.8 ± 16.3*
  • a Splenic APC were isolated from 1ASE7-3LL tumor-bearing mice, mice bearing parental 3LL tumor after treatment with the COX-2 inhibitor SC-58236, or untreated tumor-bearing controls. APC were stimulated with anti-CD40 (5 μg/ml) and IL-12 production was determined by ELISA.

  • b , p < 0.05 compared to untreated tumor-bearing mice.