Table I.

COX-2 inhibition in vivo reduces PGE2 and IL-10 production by tumor tissuesa

Tumors fromIL-10 Production (pg/ml/g of tumor tissue)PGE2 Production (ng/ml/g of tumor tissue)
Untreated mice (3LL)734 ± 7427.2 ± 1.9
CV-3LL702 ± 5729.0 ± 2.3
4SC7-3LL928 ± 10648.7 ± 4.2*
1ASE7-3LL184 ± 27*10.9 ± 2.1*
SC-58236-treated398 ± 38*16.8 ± 0.7*
Indomethacin-treated268 ± 60*12.3 ± 1.1*
  • a On day 14 after tumor inoculation, non-necrotic tumors and splenic lymphocytes were isolated from tumor-bearing mice for determination of PGE2 and IL-10 concentrations. PGE2 and IL-10 levels were evaluated in fresh tumor homogenates and in lymphocyte supernatants after 6 days in culture.

  • b , p < 0.05 compared to untreated tumor-bearing mice.