Table II.

Analysis for loci linked with gp70 IC and IgG anti-chromatin autoantibodies in B10.Az backcross micea

MarkerPositionbIgG Anti-Chromatingp70 IC
lod scorep valuelod scorep value
D1Mit80 1,522.49.3 × 10−41.40.01
Crp 1,942.02.7 × 10−32.02.5 × 10−3
D4Mit17 4,311.10.021.20.02
D4Mit349 4,820.90.051.50.01
D7Mit82 7,250.50.152.11.9 × 10−3
D10Mit297c 10,702.57.8 × 10−40.40.19
D13Mit226 c,d 13,590.30.245.54.8 × 10−7
D14Mit21 14,202.31.3 × 10−30.70.08
H2c 17,198.11.0 × 10−99.01.2 × 10−10
  • a Loci showing at least a trend (p = 0.01) for linkage with nephritis, anti-chromatin Abs, or gp70 IC are included in Table I and this table.

  • b The positions of markers are as listed in the Mouse Chromosome Committee Reports, obtainable from the Mouse Genome Database at http://www.informatics.jax.org.

  • c The disease susceptibility alleles for these loci are contributed by the B10 strain, as indicated by the direction of susceptibility in Table I.

  • d For clarity, only one marker on chromosome 13 is shown. Values for other markers tested are shown in Fig. 3.