Table I.

Amounts of cytokines in the peritoneal fluids at 24 h after CLPa

Cytokines (ng/cavity)ControlMDC (1 μg/mouse)
TNFα16.4 ± 2.210.5 ± 1.3*
MIP-224.7 ± 2.417.7 ± 1.6*
KC26.2 ± 6.110.1 ± 4.3*
MIP-1α13.5 ± 2.95.4 ± 1.4*
MCP-188.4 ± 10.453.4 ± 8.0*
  • a Mice were treated with either MDC (1 μg/mouse; 14 mice) or vehicle (11 mice) immediately after CLP. At 24 h after CLP, the mice were euthanized, and the peritoneal fluids were harvested. The amounts of cytokines in the peritoneal fluids were measured by ELISA. Two different experiments were carried out, and the data were pooled. The results were very similar in individual experiments.

  • b , p < 0.05, when compared with control.