Table I.

TREM-1-dependent regulation of cell surface activation markersa

Surface MarkerStimulation for 24 h
NeutrophilsMonocytes
Anti-MHC class IAnti-TREM-1Anti-MHC class IAnti-TREM-1
CD4023.9254.1
CD80/B7.10.60.1
CD86/B7.232.6521.5
CD54/ICAM110.935.627.097.5
CD11b0.427.9234.9256.8
CD11c75.385.7175.6385.5
CD1854.876.9198.8211.9
CD49d21.830.20.14.8
CD49e76.191.914.946.5
CD292.714.723.276.9
CD32/FcRII86.2100.272.1114.0
CD830.944.6
  • a Monocytes or neutrophils cultured for 24 h in plates either coated with anti-TREM-1 or control IgG1 (anti-MHC class I mAb). Cells were then analyzed by FACS for the indicated cell surface molecules. Numerical values indicate specific mean fluorescence intensity after subtraction of the fluorescence detected with an isotype-matched control. The shown data are representative for seven experiments.