Table I.

Effect of sTNFbp or anti-IL-1 treatment on cartilage pathologya

TreatmentInfiltration of CellsCartilage DamageProteoglycan DepletionBone Erosions
Control (BSA)1.5 ± 0.71.8 ± 0.62.3 ± 0.92.2 ± 0.7
sTNFbp0.7 ± 0.61.5 ± 0.72.0 ± 0.81.8 ± 0.5
Control (Ig)1.8 ± 0.61.6 ± 0.52.1 ± 0.52.5 ± 0.9
Anti-IL-1α+ β0.4 ± 0.3*0.4 ± 0.3*0.5 ± 0.4*0.6 ± 0.3*
  • a Joint pathology was examined after treatment either with 3 mg/kg sTNFbp every other day or with one single injection of rabbit anti-IL-1α + β (1 mg each). Histology was performed on whole knee joints as described in Materials and Methods. Scoring was performed by two independent observers on decoded slides. ∗, p < 0.001, Mann-Whitney U test, compared with controls.