Table II. Acquired N-glycosylation sites and motifs observed in Ig sequences
Sample GroupPatientFR1CDR1FR2CDR2FR3CDR3
Non-pSS controlsNC-1NFS
NC-2NIT
NC-3NSS, NSSNNTNVT, NRT
NC-4NFSNKS
pSS (before RTX)pSS-1NIS, NVSNDT, NGS, NNT, NIS, NHT, NNT, NIS, NNT, NKT, NGS, NGTNIS, NGT
pSS-2NSSNNT, NNTNVT
pSS-3NSS, NYSNNT, NNT, NNT, NNS, NIS, NLT, NNTNGT
pSS-4NFT, NFSNGT, NYTNYS, NYS, NTTNNT
pSS-5NYS, NFSNISNTT, NTSNDT, NDT, NNT
pSS (RTX plus 12 wk)pSS-1NFS, NISNNTNNT, NST, NNT, NNT, NNT,NGS
pSS-2NGT, NGTNNT
pSS-3NNT, NNT
pSS-4NVS, NFSNTT, NNT, NFSNGT
pSS-5NVS, NFTNDT, NDT, NNS, NNTNAT, NYS
pSS (RTX plus 36–52 wk)pSS-1NRT
pSS-2
pSS-3NRT
pSS-4NIS, NVTNNT, NTT, NNT, NNS, NYTNGT
pSS-5NTSNFSNVT, NDT
  • The amino acid motifs of acquired N-glycosylation sites in Ig sequences from different individuals included in this study are shown here along with their localization in CDRs or FWRs. Ac-Nglycs observed in IgG sequences are indicated in bold letters. Amino acids are designated with standard codes.

  • NC, non-pSS controls.