Table III.

Th2 cytokines are responsible for regulating diabetogenic T cells in NOD-IL-4 micea

Donor SplenocytesAb TreatmentIncidence of Diabetes (at wks)
NondiabeticDiabetic678910
NOD-IL-4Control0 /30 /30 /30 /30 /3
NOD-IL-4α-IL-40 /30 /30 /30 /30 /3
NOD-IL-4α-IL-4/α-IL-100 /31 /31 /33 /3
NODNODControl2 /75 /77 /7
NOD-IL-4NODControl0 /40 /43 /43 /44 /4b
NOD-IL-4NODα-IL-40 /53 /55 /5
NOD-IL-4NODα-IL-4/α-IL-101 /42 /44 /4
  • a Splenocytes (15 × 106) from 8 to 10-wk-old nondiabetic NOD-IL-4 or NOD mice were adoptively transferred into NOD.scid mice, with or without splenocytes (3 × 106) from recently diabetic NOD mice. Groups of mice were treated every other day for 2 wk following transfer with α-IL-4 (11B11) and/or α-IL-10 (JES2A5) or control IgG Ab. Mice were scored as diabetic when blood glucose values reached greater than 300 mg/dL. The anti-IL-4 mAb (11B11) were found effective in transplantation model (30) and anti-IL-10mAb (JES2A5) was found effective in autoimmune diabetes (50).

  • b p < 0.05 (log-rank test).