Table I.

Effects of treatment with IL-18 on the development of insulitis in NOD micea

AnimalsTreatmentDays PosttreatmentNo Insulitis (grade 0)Periinsuitis (%) (grade 1 and 2)Intrainsulitis (%) (grade 3 and 4)
BALB/c010000
NOD0172954
BALB/cIL-181410000
NOD1431978
NODIL-1814194932
BALB/cIL-182110000
NOD2192368
NODIL-1821244531
  • a Shown are the mean infiltration grades of the untreated and IL-18-treated animals. Grade 0 was defined as no periinsulitis, grade 1 as two to five mononuclear cells around the islet, grade 2 as more than five mononuclear cells surrounding the islet without intraislet infiltration and intrainsulitis, grade 3 as <20% of the intraislet area infiltrated, and grade 4 as >20% of the intraislet area infiltrated.