Table I.

Autoantibody subclass and isotype response in BABYDIAB offspring with multiple islet autoantibodies

Case No.Age at First Ab (yr)Islet AntibodiesaIgG Subclass and Isotype ResponseAge (yr) at Diabetes Onset or Last SampleHLA DR
IAAGADAIA2A
48490.8IAA, GADA, IA2AIgG1bIgG1, 2, 4, IgAIgG11.3 IDDMc4 /9
22771.7IAA, GADA, IA2AIgG1None detectedNone detected1.8 IDDM3 /4
42620.6IAA, GADA, IA2AIgG1, 2, 3IgG1, 2, 3, 4, IgEIgG12.2 IDDM3 /1
41610.9IAAIgG1, 2, 3, 42.4 IDDMNTd
16282.0IAA, GADA, IA2AIgG1, 3IgG1IgG13.2 IDDM11 /12
40050.8IAA, GADA, IA2AIgG1, 4IgG1, 4IgG13.3 IDDM3 /4
39412.0IAA, GADA, IA2AIgG1, 4IgG1IgG13.8 IDDM4 /4
18722.0IAAIgG1, 2, 3, 44.9 IDDM1 /1
10850.9IAA, GADA, IA2AIgG1, 2, 3, 4IgG1IgG15.9 IDDM3 /4
10320.8IAA, GADA, IA2AIgG1, 2, 3, 4IgG1IgG17.1 IDDM11 /2
10882.1IAA, GADA, IA2AIgG1None detectedIgG1, 2, 38.5 IDDM3 /4
70120.5IAA, GADA, IA2AIgG1, 3None detectedIgG1, 2, 3, IgM1.0NT
66371.0IAAIgG1, 2, 3, 42.0NT
50060.8IAA, GADAIgG1, 4None detected2.24 /1
62262.2IAA, GADAIgG1, 4, 2IgG12.4NT
39752.4IAA, GADAIgG1None detected2.74 /4
42042.1IAA, GADA, IA2AIgG1, 2IgG1, 3, IgEIgG1, 2, 3, IgE3.04 /1
40500.9IAA, GADA, IA2AIgG1, 2, 3, 4IgG1, 2, 4, IgMIgG1, 23.24 /4
40000.8IAA, GADAIgG1IgG1, 2, 3, IgA3.83 /1
39292.1IAA, GADA, IA2AIgG1, 4IgG1IgG1, 3, IgE4.24 /11
42152.1IAA, GADA, IA2AIgG1, 4, 2IgG1, 2IgG1, 2, 34.53 /4
17241.1IAA, IA2AIgG1IgG15.63 /4
22232.1IAA, GADA, IA2AIgG1, 2, 3, 4IgG1IgG1, IgE5.73 /4
16490.9IAA, GADA, IA2AIgG1IgG1, 4IgG16.33 /4
19485.4IAA, GADAIgG1IgG1, IgE, IgA7.34 /6
10680.9IAA, GADANone detectedIgG18.13 /1
  • a All had also ICA.

  • b The dominant subclass or isotype responses are shown in larger font.

  • c IDDM indicates diabetes onset.

  • d NT, not tested