Table I.

Autoantibody subclass and isotype response in BABYDIAB offspring with multiple islet autoantibodies

Case No.	Age at First Ab (yr)	Islet Antibodies^a	IgG Subclass and Isotype Response			Age (yr) at Diabetes Onset or Last Sample	HLA DR
Case No.	Age at First Ab (yr)	Islet Antibodies^a	IAA	GADA	IA2A	Age (yr) at Diabetes Onset or Last Sample	HLA DR
4849	0.8	IAA, GADA, IA2A	IgG1^b	IgG1, 2, 4, IgA	IgG1	1.3 IDDM^c	4 /9
2277	1.7	IAA, GADA, IA2A	IgG1	None detected	None detected	1.8 IDDM	3 /4
4262	0.6	IAA, GADA, IA2A	IgG1, 2, 3	IgG1, 2, 3, 4, IgE	IgG1	2.2 IDDM	3 /1
4161	0.9	IAA	IgG1, 2, 3, 4			2.4 IDDM	NT^d
1628	2.0	IAA, GADA, IA2A	IgG1, 3	IgG1	IgG1	3.2 IDDM	11 /12
4005	0.8	IAA, GADA, IA2A	IgG1, 4	IgG1, 4	IgG1	3.3 IDDM	3 /4
3941	2.0	IAA, GADA, IA2A	IgG1, 4	IgG1	IgG1	3.8 IDDM	4 /4
1872	2.0	IAA	IgG1, 2, 3, 4			4.9 IDDM	1 /1
1085	0.9	IAA, GADA, IA2A	IgG1, 2, 3, 4	IgG1	IgG1	5.9 IDDM	3 /4
1032	0.8	IAA, GADA, IA2A	IgG1, 2, 3, 4	IgG1	IgG1	7.1 IDDM	11 /2
1088	2.1	IAA, GADA, IA2A	IgG1	None detected	IgG1, 2, 3	8.5 IDDM	3 /4
7012	0.5	IAA, GADA, IA2A	IgG1, 3	None detected	IgG1, 2, 3, IgM	1.0	NT
6637	1.0	IAA	IgG1, 2, 3, 4			2.0	NT
5006	0.8	IAA, GADA	IgG1, 4	None detected		2.2	4 /1
6226	2.2	IAA, GADA	IgG1, 4, 2	IgG1		2.4	NT
3975	2.4	IAA, GADA	IgG1	None detected		2.7	4 /4
4204	2.1	IAA, GADA, IA2A	IgG1, 2	IgG1, 3, IgE	IgG1, 2, 3, IgE	3.0	4 /1
4050	0.9	IAA, GADA, IA2A	IgG1, 2, 3, 4	IgG1, 2, 4, IgM	IgG1, 2	3.2	4 /4
4000	0.8	IAA, GADA	IgG1	IgG1, 2, 3, IgA		3.8	3 /1
3929	2.1	IAA, GADA, IA2A	IgG1, 4	IgG1	IgG1, 3, IgE	4.2	4 /11
4215	2.1	IAA, GADA, IA2A	IgG1, 4, 2	IgG1, 2	IgG1, 2, 3	4.5	3 /4
1724	1.1	IAA, IA2A	IgG1		IgG1	5.6	3 /4
2223	2.1	IAA, GADA, IA2A	IgG1, 2, 3, 4	IgG1	IgG1, IgE	5.7	3 /4
1649	0.9	IAA, GADA, IA2A	IgG1	IgG1, 4	IgG1	6.3	3 /4
1948	5.4	IAA, GADA	IgG1	IgG1, IgE, IgA		7.3	4 /6
1068	0.9	IAA, GADA	None detected	IgG1		8.1	3 /1

a All had also ICA.
b The dominant subclass or isotype responses are shown in larger font.
c IDDM indicates diabetes onset.
d NT, not tested