Table III.

T cell responses in different cohortsa

AgNormals (%) (n = 40)Low Risk Sibs (%) (n = 51)IDDM (%) (n = 148)Prevalence IDDM vs Sibs
Tetanus toxoid90.3 (7.8 ± 1.9)100 (5.4 ± 1.6)93.8 (5.8 ± 2.1)p = 0.63
PI2.435 (2.3 ± 0.67)79 (2.7 ± 1.36)p < 0.0001
IA-2/ICA512032 (3.1 ± 0.76)78 (2.1 ± 0.44)p < 0.0001
ICA694.9 (1.8 ± 0.16)29 (1.9 ± 0.25)62 (2.3 ± 0.54)p < 0.0001
Tep69022 (1.9 ± 0.37)51 (2 ± 0.62)p < 0.0001
BSA9.6 (1.9 ± 0.6)16 (1.7 ± 0.29)55 (2 ± 0.51)p < 0.0001
ABBOS2.424 (1.9 ± 0.31)62 (2.1 ± 0.54)p < 0.0001
GAD654.9 (2.3 ± 1.12)31 (1.9 ± 0.39)55 (2.3 ± 0.61)p < 0.0001
HSP602.48 (1.9 ± 0.43)16 (2.1 ± 1)0.09
OVA000
Other controlsb000
  • a Prevalence (%) and amplitudes (mean ± SD) of positive proliferative responses to test Ags.

  • b Other control Ags (human hemoglobin, cytochrome c, actin) were tested only in 9 normals, 14 sibs, and 27–36 patients.