Table III.

K14 CD4 cells cause rapid graft-versus-host diseasea

GroupSource of BMSource of CD4 CellsNo. of CD4 CellsSurvival (days)
IB6B62 × 1064 > 250
2 × 1052 > 200
IIB6K142 × 10612, 12, 12, 13
2 × 10515, 15
IIIB6bm122 × 10614, 14, 15, 16
2 × 10523, 24
  • a B6 host animals were lethally irradiated and reconstituted with 107 T.-depleted bone marrow cells and either 2 × 105 or 2 × 106 CD4 cells purified from the animals indicated. Animals were maintained in germ-free conditions and monitored for morbidity and mortality. Survival analysis indicated that there were statistically significant differences in the survival times between groups I and II (p = 0.0001, log-rank test), groups I and III (p = 0.0007, log-rank test), and minimally, for groups II and III (p = 0.03, log-rank test).