Table I.

Summary of thyroidits and orbital pathology results

StrainExamined WeeksaTransfer CellsbThyroiditisOrbital Pathology
BALB/c4Whole ECD3/5ND
BALB/c4CD4+ ECD3/5ND
BALB/c4Whole cDNA TSHR5/55/5
BALB/c8Whole ECD8/105/10
BALB/c8CD4+ ECD4/52/5
BALB/c8Control whole0/50/5
BALB/c12Whole ECD5/55/5
BALB/cUntreated0/30/3
NOD4Whole ECD4/5ND
NOD4CD4+ ECD6/6ND
NOD4Control whole0/3ND
NOD8Whole ECD7/70/7
NOD8CD4+ ECD5/50/5
NOD8Control whole0/30/3
NOD12Whole ECD3/30/3
NODUntreated0/30/3
  • a Weeks after transfer of T cell population.

  • b Whole ECD, T cells primed with extracellular domain of the TSHR fusion protein and not fractionated; CD4+ ECD, T cells primed with the extracellular domain of the TSHR fusion protein and fractionated to yield CD4+ enriched; control whole, T cells not primed, not fractionated; whole cDNA TSHR, T cells primed by genetic immunization, not fractionated; untreated, mice receiving no T cells.