Table III.

Immunosuppressive molecules detected in six different preparations of undiluted GCSa

GCS Lot. Activity EstimatebIL-6 (pg/ml)TGF-β1 (pg/ml) (active form)CGRP (pg/ml)PGE2 (pg/ml)
A++++c1367NDNDND
B+16897065700<7
C++++5338508300<7
D+62681246000
E+++25356415500<7
F++++1392ND27600<7
  • a Cytokines that were not detected in GCS were IL-2, IL-4, IL-5, IL-10, IL-12, TNF-α, and IFN-γ.

  • b Activities of different GCS preparations were compared for modulation of IL-12, IL-10, and IFN-γ production by PBMC.

  • c ++++ and + indicate GCS preparations that had the greatest and least effects, respectively, on changing IL-12, IL-10, and IFN-γ.