Table I.

CDR3H amino acid sequences of Z22 and modified domains

MutantsSequences of VH-CDR3
WT Z-22Q A Y S N Y G A M D Y
CDR3HM1DA A D A A
CDR3HM2DA AA A
Q95EE
Q95DD
Q95HH
Y97FF
S98AA
N99QQ
N99KK
Y100FF
H3M18YKD
H3M34SN KC