Table IV.

A11-restricted influenza responses in HLA-A11/Kb transgenic mice

PeptidePositionSequenceA11 Binding Capacity (nM IC50)CTL Responsea
Peptide immunizationPR8 (FLU) immunization
No. positive/ no. testedLU30/106 cellsbNo. positive/ no. testedLU30/106 cells
Hemagglutinin63GIAPLQLGK303/611.8 (2.4)0/5c
149VTAACSHAGK1213/611.8 (2.0)0/5
243RMNYYWTLLK2.62/64.3 (1.5)0/5
450RTLDFHDSNVK516/610.3 (1.8)5/514.0 (2.2)
495SVRNGTYDYPK446/67.1 (2.3)0/5
Matrix 113SIIPSGPLK0.76/624.3 (2.0)0/5
178RMVLASTTAK1693/690.1 (1.3)0/5
220GTHPSSSAGLK946/623.5 (1.3)0/5
Matrix 270KSMREEYRK753/612.9 (1.2)0/5
Nuclear protein188TMVMELVRMIK1936/618.9 (2.0)0/5
342RVLSFIKGTK723/63.5 (1.6)0/5
  • a Peptide-pulsed .221 A11/Kb target cells.

  • b Geometric mean of positive cultures (×/÷ SD).

  • c Indicates no response detected.