Table I.

Lymphoid cellularity in reconstituted RAG2/γc micea

MouseBM Cell No. (×106)Lymphoid Cells (range in %)Thymus Cell No. (×106)Lymphoid Cells (range in %)Spleen Cell No. (×106)Lymphoid Cells (range in %)
C57BL/612.5 ± 1.6 (n = 4)25–30144 ± 22 (n = 5)81–8689.2 ± 11 (n = 6)67–74
RAG2/γc, c-abl+11.9 ± 1.4 (n = 4)13–2746.3 ± 28 (n = 6)81–8491.0 ± 23 (n = 6)64–70
RAG2/γc, c-abl−/−10.4 ± 2.4 (n = 4)14–3058.1 ± 40 (n = 6)79–8584.2 ± 15 (n = 6)62–71
RAG27.7 ± 0.5 (n = 4)10–152.3 ± 0.4 (n = 5)30–504.4 ± 1.2 (n = 5)25–40
RAG2/γc7.2 ± 0.3 (n = 4)2–100.04 ± 0.01 (n = 5)5–201.2 ± 0.1 (n = 4)10–20
  • a Red cell-depleted cell suspensions were enumerated from each organ of the indicated mice, and the percentages of lymphoid cells were measured by flow cytometry on the basis of forward and side scatter parameters.