Table I.

Effect of exogenous IL-12 on lung weight, disease severity (lung weight increase), neutrophil:macrophage ratios in lung lesions, and chlamydial lung burden after intranasal inoculation of C. psittaci B577

Lung Weight Day 12 (mg)a% Lung Weight Increase Day 12aNeutrophil:Macrophage Ratio Day 4aNeutrophil:Macrophage Ratio Day 12aC. psittaci B577 (IFU/lung) Day 12b
Control273.1 ± 109.5c158.9 ± 103.81.96 ± 1.400.25 ± 0.1111.00 ± 4.13 × 105c
(n = 16)(n = 16)(n = 4)(n = 4)(n = 4)
+IL-12182.1 ± 43.0a72.6 ± 40.7a0.51 ± 0.12b0.33 ± 0.162.89 ± 2.92 × 105∗∗
(n = 16)(n = 16)(n = 4)(n = 4)(n = 4)
  • a After inoculation of 1.9 × 106 IFU C. psittaci B577.

  • b After inoculation of 2.7 × 105 IFU C. psittaci B577.

  • c Values are mean ± SD from a representative experiment; lung weights of mock-infected BALB/c mice are 105.5 ± 6.5 mg.

  • a p = 0.016

  • b p = 0.021