Table III.

Exposure to IL-17 upregulates the expression of CD80, CD86 and MHC class II on CD11c+ DCa

PhenotypeIL-17GM-CSF (ng/ml): % Positive Cells
124
CD11c+18.036.247.2
+30.138.658.2
CD11c+CD80+7.114.721.2
+9.920.727.6
CD11c+ CD86+6.414.616.6
+11.419.121.9
CD11c+IAb+10.223.438.4
+14.326.738.3
GM-CSF (ng/ml)+ IL-4 (1000 U/ml): % Positive Cells
CD11c+43.351.465.1
+48.653.060.2
CD11c+CD80+9.212.622.1
+19.925.828.6
CD11c+CD86+16.521.029.9
+23.732.637.0
CD11c+IAb+22.731.546.5
+20.830.336.6
  • a Bone marrow-derived cells propagated in GM-CSF or GM-CSF + IL-4 for 5 days, as described in Materials and Methods, were exposed to rhuIL-17 for 18 h, then analyzed by two-color staining for coexpression of CD11c and either costimulatory (B7) molecules (CD80; CD86) or MHC class II (IAb). The data are representative of three separate experiments.