Table I.

The number of live S. aureus in human group II PLA2-transgenic mice and group II PLA2-deficient mice 3 and 12 h after the injection of the bacteria

S. aureus in Peritoneal Lavage Fluid and in Internal Organs (CFU × 102/ml lavage fluid or gram tissue)a
TransgenicPLA2-deficientpb
3 h after S. aureus i.p.
Peritoneal lavage fluid47.5 ± 14.0111.4 ± 29.20.1
Spleen118.0 ± 45.58,105.2 ± 6,391.00.04
Liver11.6 ± 4.250.2 ± 19.70.2
Kidney2.8 ± 1.545.0 ± 16.90.005
Lung7.5 ± 4.017.8 ± 4.20.08
12 h after S. aureus i.p.
Peritoneal lavage fluid3.0 ± 1.116,257.4 ± 9,709.20.02
Spleen4.6 ± 1.92,362.1 ± 1,857.10.001
Liver25.8 ± 22.2154.3 ± 83.20.04
Kidney0.6 ± 0.299.9 ± 55.80.05
Lung0.6 ± 0.2109.5 ± 54.30.05
  • a Mean ± SEM (n = 8–12).

  • b The p values represent the significances of the differences in the number of live bacteria between transgenic and PLA2-deficient mice in peritoneal lavage fluid or in internal organs in the Mann-Whitney U test.