Table I.

Collagen-induced arthritis in CD28+/+, CD28+/−, and CD28−/− DBA/1 mice

GenotypeIncidence of DiseaseArthritis Indexa
Expt. 1
CD28+/+6/8 (75.0%)4.3 ± 0.9
CD28+/−6/8 (75.0%)4.3 ± 1.1
CD28−/−0/5 (0.0%)
Expt. 2
CD28+/−8/10 (80.0%)6.6 ± 0.4
CD28−/−0/8 (0.0%)
Expt. 3
CD28+/−6/8 (75.0%)5.8 ± 1.9
CD28−/−0/6 (0.0%)
  • a Mean ± SEM of the maximal scores of arthritic mice.