Table II.

Dichotomy in tissue distribution, CD1d dependency, and phenotype of NKT cells

NKT CellsPreferential Tissue DistributionCD1d DependencyTCR RepertoireCD4/CD8 ExpressionActivation PhenotypeNK Cell Markersa
Type IThymusDependentBiasedbCD4+, DNActivatedcLow
Liver
Type IISpleenIndependentDiverseCD8+, DNNaivecHigh
Bone marrow
  • a Ly49A and DX5.

  • b Preferential expression of Vα14 and Vβ8.2.

  • c Activated NKT cells are CD62L and CD69+, whereas naive NKT cells are CD62L+ and CD69.