Table I.

Tissue distribution of NKT cells in C57BL/6 wild-type and mutant micea

StrainThymusLiverSpleenBone MarrowPBL
C57BL/621 ± 822 ± 71.2 ± 0.53.1 ± 0.90.5 ± 0.1
nu/nu 0.5 ± 0.40.5 ± 0.30.2 ± 0.1n.d.
CD1d−/−1.8 ± 0.83.4 ± 1.90.5 ± 0.11.4 ± 0.3n.d.
Jα281−/−2.0 ± 0.62.8 ± 0.80.5 ± 0.10.8 ± 0.1n.d.
  • a The percentage of NK1.1+ TCR-β+ cells was determined in HSA thymocytes, total mononuclear cells in liver and PBL, and B cell-depleted mononuclear cells in spleen and bone marrow (see Materials and Methods). Data are expressed as the mean ± SD of three to five individual mice per group. All mutant mice were backcrossed to C57BL/6 for at least three generations.