Table I.

Effect of lung KC overexpression on bacterial clearance in Klebsiella pneumoniaa

SiteTreatmentK. pneumoniae CFU (48 h)
Plasmawt12.3 ± 1.9
KC-transgenic3.1 ± 1.7b
Lungwt117.5 ± 2.6 × 104
KC-transgenic8.7 ± 2.2 × 104c
  • a The effect of KC overexpression on K. pneumoniae bacterial clearance in lung homogenates and plasma at 48 h postinoculation is shown (3 × 103 CFU).

  • b p < 0.02;

  • c p < 0.005 (transgenic mice compared with wt control mice). n = 16 mice per group at 48 h. Data are means ± SEM.