Table I.

Kinetics of the serum IL-12 response to CpG in wt and IFN-γ deficient mice

MiceTreatmentKinetics of Serum IL-12 Levels After Treatmenta
1 h4 h12 h24 h
wtPBS6612110993
wtCpG175348213401591
GKOPBS735792542489
GKOCpG16381388135405
  • a IL-12 levels are given in picograms per milliliter and are measured by ELISA on serum from BALB/c mice (two to four mice/group) with (wt) or without (GKO) a functional IFN-γ gene at the times specified following the indicated treatment. The SD of the triplicate wells was <5%.