Table I.

Cytokine-induced functional properties of BMDM

Cytokine (concentration)aNitrite Concentration (arbitrary units)Uptake of Apoptotic PMNsβ-Glucuronidase Expression Scores
Control2.7 ± 1.829.4 ± 3.52.3 ± 0.2
IFN + TNF (20 U/ml, 10 ng/ml)22 ± 3.2b17.1 ± 2.4c1.3 ± 0.2c
IFN (20 U/ml)5.2 ± 2.0b21.6 ± 2.0c
TNF (10 ng/ml)2.5 ± 2.640.1 ± 3.81.8 ± 0.3
IGF (7.5 ng/ml)1.7 ± 1.626 ± 2.73.5 ± 0.1c
IL-4 (5 μl/ml)1.9 ± 1.613 ± 1.4b2.1 ± 0.2
IL-10 (100 ng/ml)3.2 ± 2.522.8 ± 2.70.7 ± 0.3c
  • a Concentrations shown are those with maximum effect.

  • b p < 0.05 relative to unstimulated control

  • c p < 0.05 relative to unstimulated controls