Table II.

IgE-mediated enhancement of the Ab response in different mouse strainsa

StrainnfH-2IgG anti-BSA
log10 U/ml ± SDb (Geom. mean)cSIdpe
IgE + BSA-TNPBSA-TNP
BALB/c3/4d4.46 ± 0.21 (28840)2.23 ± 0.27 (170)1700.001
CBA/J4/4k4.95 ± 0.43 (89125)3.09 ± 0.30 (1230)720.001
DBA/13/4q4.33 ± 0.09 (21380)2.69 ± 0.21 (490)440.001
DBA/24/4d5.17 ± 0.03 (147911)3.42 ± 0.01 (2630)560.001
SJL/J4/4s4.56 ± 0.34 (36308)2.85 ± 0.24 (708)510.001
SWR5/4q5.09 ± 0.14 (123027)2.81 ± 0.25 (646)1900.001
B10.Q3/2q4.71 ± 0.01 (51286)2.64 ± 0.18 (437)1170.001
B10.P4/3p4.58 ± 0.17 (38019)2.47 ± 0.21 (295)1290.001
B103/3b2.46 ± 0.20 (288)2.14 ± 0.56 (138)2.1NS
B63/3b2.48 ± 0.33 (302)2.91 ± 0.41 (813)0.4NS
129/Sv3/2b4.10 ± 0.19 (12589)3.92 ± 0.08 (8318)1.5NS
(B6× CBA/J)F14/4b× k4.56 ± 0.14 (36308)2.64 ± 0.57 (437)830.001
(B6× DBA/2)F13/3b× d5.10 ± 0.07 (125893)3.45 ± 0.09 (2818)450.001
(BALB/c× 129/Sv)F13/3d× b4.61 ± 0.19 (40738)2.86 ± 0.21 (724)560.001
(B6× 129/Sv)F13/4b× b3.68 ± 0.23 (4786)3.32 ± 0.07 (2089)2.30.05
  • a Mice were immunized with 50 μg TNP-specific IgE (mAb IGELb4) and 20 μg BSA-TNP. Controls received Ag alone. Sera were tested for BSA-specific IgG Abs 7 days after immunization.

  • b Mean of log10 U/ml ± SD.

  • c Geometrical mean.

  • d Stimulation index.

  • e p value as determined by Student’s t test, NS (p > 0.05).

  • f Number of mice in Ab+Ag group/Ag group.