Table V.

IFN-γ induces apoptosis in MRL-Faslpr TECa

MediaIFN-γTEC MRL-Faslpr (%)
IFN-γR−/−IFN-γR+/+
Adherent+3.8 ± 1.23.2 ± 1.4
++2.4 ± 2.023.0 ± 2.3b
Detached+NCNC
++NC29.0 ± 14.0
  • a Apoptotic cells detected by TUNEL method in adherent and detached TEC as described in Materials and Methods. IFN-γ was at 50 U/ml.

  • b p < 0.001 IFN-γR+/+ vs IFN-γR−/− or media alone, ANOVA. NC, no cells.