Table IV.

IFN-γR signaling is required for increased apoptosis in MRL-Faslprkidneya

MRL++MRL-Faslpr
IFN-γR−/−IFN-γR+/−
Apoptosis
Glomeruli0 ± 00.5 ± 0.64 ± 2.7b
Inter/Perivasc0 ± 00.8 ± 0.37 ± 4.6b
  • a Apoptotic cells determined by counting TUNEL-positive cells/15 glomeruli and in 100 μm2 Inter/Perivasc (interstitial/perivascular) area (×400).

  • b p < 0.001 IFN-γR+/− vs IFN-γR−/−; n = 4 in each group, Mann-Whitney test.