Table II.

IFN-γ, but not MRL-Faslpr sera, induces CSF-1 in MRL-Faslprmesangial cellsa

SerabMRL-Faslpr
MRL-FaslprC3HcIFN-γdIFN-γR−/−IFN-γR+/−
+0 ± 00 ± 0
+0 ± 00 ± 0
+0 ± 02.3 ± 0.6
++0 ± 02.2 ± 0.4
  • a CSF-1 scored from 0 (none), 0.5 (trace), 1 (mild), 2 (moderate), to 3 (maximum) as described in Materials and Methods.

  • b Sera, pooled from 5 MRL-Faslpr mice, 6 mo of age.

  • c Sera, pooled from four age-matched C3H mice.

  • d rIFN-γ: 50 U/ml.