Table I.

CSF-1 is not expressed and TNF-α is down-regulated in IFN-γR-deficient MRL-Faslprkidneysa

MRL-Faslpr
IFN-γR−/−IFN-γR+/−MRL-Faslpr
CSF-1
Glomeruli0 ± 0 (6)2.5 ± 0.2 (4)*3.0 ± 0 (3)*
Inter/Perivasc0 ± 0 (6)1.0 ± 0.5 (4)*2.0 ± 0.5 (3)*
TNF-α
Glomeruli0.8 ± 0.4 (6)1.8 ± 0.5 (4)**2.0 ± 0.5 (4)**
Inter/Perivasc1.3 ± 0.3 (6)2.5 ± 0.4 (4)**2.8 ± 0.7 (3)**
  • a CSF-1 and TNF-α staining were performed by the immunoperoxidase method. Intensity of staining graded from 0 (none), 0.5 (trace), 1 (mild), 2 (moderate), and 3 (maximum); Inter/Perivasc, interstitial/perivascular areas; *p < 0.001 IFN-γR deficient vs IFN-γR intact; **p < 0.01 IFN-γR deficient vs IFN-γR intact MRL-Faslpr mice; 6 mo of age. Numbers in parentheses = n.