Table IV.

Heterogeneity in CD8+ T cell responses to gp100 peptides

gp100 PeptidePatient ID
191436458460468482
MLGTHTMEV00013.0a0b0
AVIGALLAV000069.50
YLAEADLSYT000000
RLMKQDFSV000000
AMLGTHTMEV000000
IMPGQEAGL6.110.7008.40
HLAVIGALL007.7000
LMAVVLASL000000
FLRNQPLTFA0−10.30000
QLVFGIELMEV0000014.8
  • a Number of vaccine-induced peptide-specific CD8+ IFN-γ-secreting T cells/500,000 PBL. These were calculated by subtracting the number of peptide-specific CD8+ T cells present prior to immunization from that after four immunizations in the same patient.

  • b 0, Values that were between −4.9 and 4.9 after subtraction of the pre-immunization response. This range on either side of 0 is approximately twice the maximum standard deviation of our assay.