Table III.

Vaccine-induced CD8+ T cell responses to melanoma-associated Ags

Patient IDgp100TyrosinaseMelan-A/MART-1MAGE-3TRP-2MC1RAny Peptide
1916.1a0b0000+
3750045.589.200+
418008.310.600+
42200011.800+
43610.7, −10.3c22.4, −6.30036.1, 16.6d23.4, 13.7+
4420008.2, 5.800+
443−5.500000
445000000
4587.7011.70022.2+
46013.011.50000+
462000000
465000000
467021.8, 6.80000+
46869.5, 8.400037.1, −19.00+
471000000
475000−17.600
477000000
478017.112.70−6.40+
479013.40015.40+
48214.800000+
483000000
484000000
%27%23%18%18%13%9%59%
  • a Number of vaccine-induced peptide-specific CD8+ T cells/500,000 PBL. These were calculated by subtracting the number of peptide-specific CD8+ T cells present prior to immunization from that after four immunizations in the same patient.

  • b 0, Values that were between −4.9 and 4.9 after subtraction of the preimmunization response. This range on either side of 0 is approximately twice the maximum standard deviation of our assay.

  • c A value with a − indicates that the pre-immunization response was greater than the postimmunization response.

  • d Multiple values indicate stimulation of CD8+ T cells to more than one peptide on the same Ag.