Table I.

Summary of surface marker modulations on CTL activated in vitro and in vivoa

Surface MarkerIn Vitro Cell Division NumberbIn Vivo Cell Division Numberc
0123456012345
CD25↑↑↑↑↑↑↑↑↑↑↑↑↑
CD69↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑
CD62L↓↓↓↓↓
CD44↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑
Fas↑↑↑↑
FasL↑↑↑↑NDNDNDNDNDND
TCR↓↓↓↓↓↓dd↓↓d↓↓↓d↓↓↓dNVd
  • a Marker modulations are compared to naive 318 CTL: ↔, no modulation; ↑, 0- to 5-fold up-regulation; ↑↑, 5- to 10-fold up-regulation; ↑↑↑, ≥10-fold up-regulation; ↓, 0- to 5-fold down-regulation; ↓↓, 5- to 10-fold down-regulation; ↓↓↓, ≥10-fold down-regulation; ND, not done; NV, not visible.

  • b Data taken from Fig. 1.

  • c Data taken from Fig. 3.

  • d Data taken from Fig. 4.